Radical scavenger and antihepatotoxic activity of Ganoderma formosanum,Ganoderma lucidum and Ganoderma neo-japonicum |
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| Affiliation: | 1. Graduate Institute of Natural Products, Kaohsiung Medical College, 100 Shih Chuan 1st Rd., Kaohsiung, 807, Taiwan, R.O.C.;2. Tainan Municipal Hospital, Department of Internal Medicine, Tainan City, Taiwan, R.O.C.;3. Japan Food Research Laboratories, Nagoya Branch, Oosu, Naka-Ku, Nagoya, 460, Japan;4. Toyo Hakko Company Ltd., 6–82 Chuou, Obu, Aichi 474, Japan;1. Functional Omics and Bioprocess Development Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia;2. Biomass Energy Laboratory, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia;3. Bioresources and Bioprocessing Research Group, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia;4. Institute for Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Belgrade, Serbia;5. Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya, Kuala Lumpur, Malaysia;6. Halal Action Laboratory, Kolej GENIUS Insan, Universiti Sains Islam Malaysia, Bandar Baru Nilai, 71800, Nilai, Negeri Sembilan, Malaysia;7. Agro - Biotechnology Institute, Malaysia (ABI), National Institutes of Biotechnology Malaysia (NIMB), C/ o HQ MARDI, 43400, Serdang, Selangor, Malaysia;8. Bioscience Research Institute, Athlone Institute of Technology, Dublin Road, N37 WO89 Athlone, Westmeath, Ireland;1. Pharmacy College, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;2. Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;3. Institute of Edible Fungi, Fujian Academy of Agricultural Sciences, Fuzhou 350013, PR China;1. Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria;2. Institute of Pharmacy/Pharmaceutical Chemistry, Computer-Aided Molecular Design Group, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria;3. Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;4. Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;1. State Key Laboratory of Forest and Soil Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110164, China;2. Department of Botany, National Museum of Natural Science, Taichung 404, Taiwan, China;3. Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, CZ-370 05 České Budějovice, Czech Republic;4. The Connecticut Agricultural Experiment Station Valley Laboratory, 153 Cook Hill Road, Windsor, CT 06095, USA;1. University of Belgrade, Faculty of Biology, Takovska 43, 11000 Belgrade, Serbia;2. Institute of Oncology and Radiology of Serbia, Pasterova 14, 11 000 Belgrade, Serbia;3. University of Belgrade, Institute for Biological Research “Siniša Stanković“, Bulevar Despota Stefana 143, 11000 Belgrade, Serbia |
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| Abstract: | The free radical scavenging and antihepatotoxic activity from Ganoderma lucidum, Ganoderma formosanum and Ganoderma neo-japonicum were studied. Treatment with the water extract of Ganoderma lucidum, Ganoderma formosanum and Ganoderma neo-japonicum caused a marked decrease in the CCl4-induced toxicity in rat liver, made evident by their effect on the levels of glutamic oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH) in the serum. The scavenging potency of the water extracts of the crude drugs was evaluated in terms of their ability to reduce the peaks of spin adducts using electron spin resonance (ESR) spin-trapping techniques. The results indicated that Ganoderma formosanum showed the greatest antihepatotoxic activity and the greatest free radical scavenging activity. |
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