Tumor necrosis factor production by human T-cells stimulated with bacterial superantigens |
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| Affiliation: | 1. Laboratory for coastal marine eco-environment process and carbon sink of Hainan provincet/Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya 572022, China;2. National Marine Environmental Monsitoring Center, Dalian 116023, China;3. College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China;4. School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China;1. Joining and Welding Research Institute, Osaka University, 11-1 Mihogaoka, Ibaraki-shi, Osaka 567-47, Japan;2. Japan Atomic Energy Agency, 1-1-1 Kouto, Sayou-cho, Sayou-gun, Hyogo 679-5148, Japan;3. Industrial Research Institute of Ishikawa, 2-1 Kuratsuki, Kanazawa, Ishikawa 920-8203, Japan;4. Graduate School of Engineering, Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan;5. Graduate School of Science and Engineering, Kindai University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan;6. Muratani Machine Inc., 1-32 Higashikagatsumemachi, Kanazawa, Ishikawa 920-0209, Japan;7. Tokyo University of Technology, Department of Mechanical Engineering, 1404-1 Katakura, Hachiouji, Tokyo 192-0914, Japan |
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| Abstract: | Tumor necrosis factor (TNF) production from T-cells stimulated with superantigenic exotoxins, staphylococcal enterotoxin B and streptococcal pyrogenic exotoxin A was investigated in the presence of cells bearing distinct isotypes of HLA class II molecules. The main T-cell subset for TNF production was investigated in parallel. Similarly high levels of TNF production were induced upon stimulation with the toxins in the presence of DR+ or DQ+ cells, but only marginal levels of TNF production were induced in the presence of DP+ cells. Although both CD4+ T-cells and CD8+ T-cells produced TNF-α and TNF-β in response to toxin stimulation in the presence of HLA class II+ cells, the former T-cell subset was the major source of producers of TNF-α and TNF-β. |
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