A comparison of the lactational and transplacental deposition of mercury in offspring from methylmercury-exposed mice. Effect of seleno-L-methionine |
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| Affiliation: | 1. Institute of Community Health, Odense University, Winslowparken 17, DK-5000 Odense C, Denmark;2. Institute for Life Sciences and Chemistry, Roskilde University Center, P. 0. Box 260, DK-4000 Roskilde, Denmark;1. Department of Animal Reproduction Biotechnology and Environmental Hygiene, West Pomeranian University of Technology, Szczecin, Janickiego 29, 71-270, Szczecin, Poland;2. Department of Microbiology and Biotechnology, West Pomeranian University of Technology, Szczecin, Al. Piastów 45, 70-311, Szczecin, Poland;3. Laboratory of Biostatistics, West Pomeranian University of Technology, Szczecin, Janickiego 29, 71-270, Szczecin, Poland;4. Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Institute of Chemistry and Chemical Technologies, Lviv Polytechnic National University, 79000, Lviv, Ukraine;5. Department of Environmental Management, West Pomeranian University of Technology, Szczecin, Ul. Juliusza Słowackiego 17, 71-434, Szczecin, Poland;1. , Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China;2. , School and Hospital of Stomatology, Department of Oral Pathology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases. Shenyang, 110001, China;1. Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium;2. Laboratory of Infectious and Parasitic Diseases, Veterinary Research Institute, Hellenic Agricultural Organization - DEMETER, 57001, Thermi, Thessaloniki, Greece;3. Parasitology, Department of Paraclinical Science, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 369 Sentrum, 0102, Oslo, Norway;1. Dep of Food, Water and Cosmetics, Norwegian Institute of Public Health, PO Box 4404, 0403 Oslo, Norway;2. GenØk – Centre for Biosafety, PO Box 6418, 9294 Tromsø, Norway;3. Dep of Air Pollution and Noise, Norwegian Institute of Public Health, PO Box 4404, 0403 Oslo, Norway;4. Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University for Science and Technology, Trondheim, Norway |
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| Abstract: | Females exposed to methylmercury expose their offspring to mercury across the placenta as well as through milk. The relative importance of these two routes of exposure has hitherto been unresolved. Using a cross-fostering model with female mice, the transplacental and lactational exposures to mercury were evaluated separately. In female mice exposed to low, non-toxic levels of methylmercury in the drinking water the deposition of mercury in offspring before birth was quantitatively more important than later transfer of mercury from milk to offspring. Seleno-l-methionine supplementation of the dams increased the whole-body deposition in offspring. As methylmercury is anticipated to be absorbed completely and the young mice are unable to excrete mercury, these data indicate that seleno-l-methionine affects the kinetics of the inorganic mercury pool, which, due to demethylating processes, is present in both blood and milk of methylmercury-exposed females. |
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