Lung transplantation in patients with cystic fibrosis |
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| Affiliation: | 1. Department of Traumatology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland;2. Centre on Aging and Mobility, University Hospital Zurich, and City Hospital Waid Zurich, Tièchestrasse 99, 8037 Zurich, Switzerland;3. Department of General, Visceral and Thoracic Surgery, Bürgerspital Solothurn, Schöngrünstrasse 42, 4500 Solothurn, Switzerland;1. University of Oslo, Faculty of Medicine, PB 1078 Blindern, 0316 Oslo, Norway;2. Division of Epidemiology, National Institute of Public Health, PB 4404, Nydalen, 0403 Oslo, Norway;3. Department of Global Public Health and Primary Care, University of Bergen, PB 7804, 5018 Bergen, Norway;4. Department of Health Registries, Norwegian Institute of Public Health, Kalfarveien 31, 5018 Bergen, Norway |
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| Abstract: | Worldwide more than 600 heart-lung or lung transplantations have been performed in patients with cystic fibrosis and end-stage respiratory disease. At the University Hospital in Groningen 10 patients with cystic fibrosis underwent bilateral sequential lung transplantation until April 1994. The 1-year survival was 76%, which is similar to that of lung transplant recipients with other diseases. Postoperative problems were mainly related to acute rejection, chronic graft dysfunction and infection. The main problem for further extension of the lung transplantation program is the persistent shortage of usable donor-organs for cystic fibrosis patients, especially of small-sized donors. |
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