Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis) |
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| Affiliation: | 1. College of Oriental Medicine, Dongshin University, Naju, Jeonnam 58245, South Korea;2. College of Veterinary Medicine, Chonnam National University, Gwangju 61186, South Korea;3. Department of Biotechnology, Sangmyung University, Seoul 03016, South Korea;4. Jeollanam-do Forest Resource Research Institute, Naju, Jeonnam 58213, South Korea;5. College of Engineering, Mokpo National University, Muan, Jeonnam 58554, South Korea;6. College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon 24341, South Korea;7. College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan, Jeonnam 58554, South Korea;1. Child Health Evaluative Sciences Program, The Hospital for Sick Children Research InstituteToronto, Ontario, Canada;2. Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;3. Division of Pediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada;4. Newborn Screening Ontario, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada;5. Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;6. Division of Hematology, The Hospital for Sick Children, Toronto, Ontario, Canada |
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| Abstract: | The effect of the hot water extract of black tea (Camellia sinensis (L.) O. Kuntze, Theaceae) on ulceration induced by various ulcerogens and by cold restraint stress (CRS) was investigated in albino rats. While prior administration of tea extract for 7 days significantly reduced the incidence of ulcer, ulcer number and ulcer index produced by aspirin, indomethacin, ethanol, reserpine and CRS, it failed to inhibit the ulcers induced by serotonin and histamine. Tea extract also favourably altered the changes in acid and peptic activity of gastric secretion induced by aspirin, indomethacin, ethanol, reserpine and CRS. The observations suggest that the hot water extract of black tea possesses anti-ulcer activity, probably mediated through prostaglandins. |
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