Effects of vinca alkaloids on rat parotid and submandibular glands function in vivo |
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| Institution: | 1. Nutrition Safety Policy Division, Food Nutrition and Dietary Safety Bureau, Ministry of Food and Drug Safety, Cheongju, 361-951, Republic of Korea;2. Food and Nutrition Major, Division of Food Science and Culinary Arts, Shinhan University, Dongducheon 480-777, Republic of Korea;3. Department of Food and Nutrition, Sookmyung Women''s University, Seoul, Republic of Korea;4. Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea;1. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran;2. Department of Physiology and Pharmacology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran;3. Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;4. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Biology, Faculty of Sciences, Gonbad Kavous University, Gonbad, Iran;6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran;7. Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran;8. Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran;9. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran;1. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran;3. International Campus, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada |
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| Abstract: | - 1.1. Vincristine (1 mg/kg) and vinblastine (2 mg/kg) were injected intraperitoneally into the rats, 24 hr before the experiments.
- 2.2. Animals were anesthetized with 50 mg/kg of sodium pentobarbital and saliva was collected from vincristine-treated, vinblastine-treated and control animals using 8 mg/kg of pilocarpine as secretagogue.
- 3.3. Parotid saliva was analyzed for protein, amylase and Ca2+ content, and submandibular saliva for flow rate, protein and Ca2+ concentration.
- 4.4. Saliva from two treated groups was significantly lower (P < 0.01) in flow rate, amylase and protein content than that of control groups. Calcium level was significantly increased (P < 0.05) in treated animals.
- 5.5. It is concluded that the antisecretory effects of vinca alkaloids may be consistent with their actions on salivary cell microtubules.
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