Pharmacological evidence that nitric oxide can act as an endogenous antipyretic factor in endotoxin-induced fever in rabbits |
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| Institution: | 1. School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, China;2. China North Engine Research Institute, Tianjin, 300400, China;1. Department of Neuroscience, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532 WI, USA;2. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran;3. Department of Agronomy and Plant Breeding, College of Agriculture, Isfahan University of Technology, Isfahan 84156-83111, Iran |
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| Abstract: | - 1.1. This study investigates the effects of the nitric oxide donors on lipopolysaccharide-induced fever in rabbits, and the effect of brain nitric oxide synthase inhibition on the febrile response in pyrogen tolerant animals.
- 2.2. The febrile response was reduced by intravenous injections of the nitric oxide donors molsidomine (1.0 mg/kg) and isosorbide dinitrate (0.5 mg/kg) 60min after intravenous treatment with lipopolysaccharide.
- 3.3. The magnitude of fever was also attenuated by intracerebroventricular administration of molsidomine (75 μg).
- 4.4. Intracerebroventricular pretreatment with the nitric oxide synthase inhibitor, NG-nitro-l-arginine (100μg) 10 min before the injection of lipopolysaccharide significantly enhanced the febrile response in pyrogen tolerant animals.
- 5.5. The results suggest that nitric oxide is involved in the central mechanisms of thermoregulation during fever as one of the effective endogenous antipyretics.
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