Involvement of B-1 cells in mucosal immunity and autoimmunity |
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| Affiliation: | 1. Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea;2. Department of Biochemistry, Chungnam National University, Daejeon, South Korea;3. University of Science and Technology (UST), Daejeon, South Korea;4. Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea;1. Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, New Delhi, India;2. Amity Institute of Virology & Immunology, Amity University, Noida, Uttar Pradesh, India;3. Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India;4. Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, GTB Nagar, Delhi, India;1. Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan;2. Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan;3. Laboratory of Molecular Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan |
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| Abstract: | B-1 cells are distinguished from conventional B cells by their antomical localization, surface phenotypes and functional characteristics. The physiological functions and pathological roles of these cells remain controversial. In this review, Masao Murakami and Tasuku Honjo summarize recent evidence for the involvement of B-1 cells in mucosal immunity and autoimmunity, and discuss the relationship between these phenomena. |
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