Age-related activity of catalase in different genotypes of drosophila melanogaster |
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| Institution: | 1. Laboratory of Forest Pathogen Integrated Biology, Research Institute of Forestry New Technology, Chinese Academy of Forestry, Beijing, PR China;2. Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu, PR China;1. Normandy University, UNICAEN, Sorbonne Universités, MNHN, UPMC Univ Paris 06, UA, CNRS, IRD, Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), F-14032 Caen, France;2. UPMC, CNRS, FR2424, ABiMS, Station Biologique, F-29680 Roscoff, France;3. Normandy University, UNIROUEN, INSERM, U1239, Laboratoire Différenciation et Communication Neuronale et Neuroendocrine, Institut de Recherche et d’Innovation Biomédicale de Normandie, F-76000 Rouen, France;4. Equipe CORINT, UMR CNRS 6226, PRISM, CS 34317, Campus de Villejean, Université de Rennes 1, F-35043 Rennes, France;5. Normandy University, Post Genomic Platform PROTEOGEN, SF ICORE 4206, F-14032 Caen, France;6. Normandy University, CIMAP, UMP 6252 (CEA/CNRS/ENSICAEN/Normandy University), Caen, France;1. State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071, China;2. State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China;1. Department of Agricultural Food, and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada;2. Departamento de Mejora Genética Animal INIA, 28040, Spain;3. Unidad de Tecnología en Producción Animal, CITA, 59059 Zaragoza, Spain;4. Instituto de Parasitología y Biomedicina “López-Neyra”, IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento s/n, Armilla, 18100 Granada, Spain;5. ARAID, 50004 Zaragoza, Spain |
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| Abstract: | The enzyme catalase protects aerobic organisms from oxygen free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical. This damage has been implicated in the increased risk of disease and death associated with aging. In order to study the age-specific activity of catalase in male D. melanogaster three different genotypes (Oregon w.t., ebony mutant, and the F1 hybrids of the two), whose mean life spans are about 55, 40, and 63 days, respectively, were used in the experiments. As the mean life span of the mutant is the shortest the enzyme activity was measured until the 43rd day, whereas in Oregon w.t., it continued until the 72nd day and in hybrids until the 79th day (longest-lived group). Although the enzyme activity in mutant flies increased sharply till the 9th day (and attained the highest level), later it declined sharply. In the other genotypes, the enzyme activity increased gradually until the 20–25th days, and then declined steadily in comparison to that of the ebony mutant. We found that higher catalase activity is associated with reduced life span for ebony mutant. It is obvious that some relationship exists between life span and antioxidant enzymes; however, a review of the literature does not at the moment allow as to understand the underlying mechanism involved in aging. |
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