Immunomodulating effects of the new anti-rheumatic drug tenidap on collagen-induced arthritis |
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| Institution: | 1. School of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden;2. Region Västra Götaland, Närhälsan, Gothenburg, Sweden;3. Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden;4. Region Västra Götaland, Sahlgrenska University Hospital, Department of Acute Medicine and Geriatrics, Gothenburg, Sweden;5. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden;6. Region Västra Götaland, Sahlgrenska University Hospital, Neurology Clinic, Gothenburg, Sweden;7. Biostatistics, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden;8. Region Västra Götaland, Regionhälsan, Gothenburg, Sweden;9. R&D Centre Gothenburg and Södra Bohuslän, Sweden;10. Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden;11. Region Västra Götaland, Angered Hospital, Gothenburg, Sweden;12. Institute for Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany;13. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden;14. Region Västra Götaland, Sahlgrenska University Hospital, Psychosis Clinic, Gothenburg, Sweden |
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| Abstract: | We investigated the in vivo action of the newly developed anti-rheumatic agent tenidap, CP-66,248 (Pfizer Inc., New York), on arthritis in collagen-induced arthritic mice. The inhibitory effect of tenidap on the development of arthritis was statistically more significant than piroxicam. The serum anti-type II collagen antibody titer was markedly inhibited in the mice treated by tenidap. These results suggest that, unlike NSAIDs, tenidap inhibits the progress of collagen-induced arthritis through its immunomodulating effect. |
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