| 氯氮平对血浆神经肽Y及体质量的影响 |
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| 引用本文： | 宋梓祥,陈琪,徐乐平,赵蓓,仲爱芳,端义扬. 氯氮平对血浆神经肽Y及体质量的影响[J]. 临床精神医学杂志, 2009, 19(2) |
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| 作者姓名： | 宋梓祥 陈琪 徐乐平 赵蓓 仲爱芳 端义扬 |
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| 作者单位： | 江苏常州市解放军第一○二医院精神科,213003;江苏常州市解放军第一○二医院精神科,213003;江苏常州市解放军第一○二医院精神科,213003;江苏常州市解放军第一○二医院精神科,213003;江苏常州市解放军第一○二医院精神科,213003;江苏常州市解放军第一○二医院精神科,213003 |
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| 摘 要： | 目的:探讨氯氮平对精神分裂症患者血浆神经肽Y(NPY)及体质量的影响。方法:30例女性精神分裂症患者(氯氮平组),于氯氮平治疗前、治疗4周,分别测定体质量、血浆NPY水平,并与30例健康成年女性(对照组)比较。结果:氯氮平组治疗前血浆NPY(pg/ml)与对照组比较,差异无统计学意义(58.9±12.3,60.9±14.0,P>0.05);治疗后,氯氮平组体质量及血浆NPY均高于治疗前,差异有统计学意义(63.3±13.3,60.9±14.0;159.2±66.1,129.0±66.5,P<0.05)。治疗后、治疗前血浆NPY的差值,与治疗前后体质量的差值呈正相关(r=0.446,P=0.013)。结论:氯氮平引起体质量增加的同时,伴有血浆NPY增高,后者可能参与了氯氮平所致的体质量增加形成机制。
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| 关 键 词： | 氯氮平 精神分裂症 体质量 神经肽Y |
Effects of clozapine on plasma neuropeptide Y (NPY) levels and body weight regulations |
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| SONG Zi-xiang,CHEN Qi,XU Le-ping,ZHAO Pei,ZHONG Ai-fang,DUAN Yi-yang. Effects of clozapine on plasma neuropeptide Y (NPY) levels and body weight regulations[J]. Journal of Clinical Psychological Medicine, 2009, 19(2) |
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| Authors: | SONG Zi-xiang CHEN Qi XU Le-ping ZHAO Pei ZHONG Ai-fang DUAN Yi-yang |
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| Affiliation: | SONG Zi-xiang,CHEN Qi,XU Le-ping,ZHAO Pei,ZHONG Ai-fang,DUAN Yi-yang.Department of Psychiatry,The PLA 102 nd Hospital,Changzhou 213003,China |
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| Abstract: | Objective: To investigate the effects of clozapine on plasma neuropeptide Y(NPY)levels and body weight regulations in schizophrenic patients. Method:30 female patients with schizophrenia(patient group)were involved in the study.Body weight and plasma neuropeptide Y levels were measured in patient group before and after 4-week treatment with clozapine,and compared with 30 female healthy controls(control group). Results:The plasma NPY levels(pg/ml)in patient group before treatment showed no significant differ... |
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