复方甘草酸苷联合放化疗治疗中晚期食管癌临床观察

目的:观察复方甘草酸苷联合放化疗治疗中晚期食管癌的疗效和毒副反应。方法:将88例中晚期食管癌患者随机分为治疗组(复方甘草酸苷联合放化疗治疗)与对照组(单纯放化疗治疗),3wk为1个疗程,完成2个疗程后评价2组疗效和毒副反应。结果:治疗组与对照组有效率分别为70.5%、59.1%(P<0.05);对照组发生放射性食管炎、肝肾功能损害、消化道反应及骨髓抑制的程度重于治疗组(P<0.05)。结论:复方甘草酸苷联合放化疗治疗中晚期食管癌疗效好,可减轻毒副反应。

Compound Glycyrrhizin plus Chemoradiotherapy for Advanced Esophageal Carcinoma: Observation of Clinical Efficacy

OBJECTIVE:To observe the efficacy and toxicity of compound glycyrrhizin(Stronger Neo-Minophagen C SNMC) plus chemoradiotherapy in treating advanced esophageal carcinoma.METHODS:A total of 88 patients with advanced esophageal carcinoma were randomly assigned to receive compound glycyrrhizin in combination with chemoradiotherapy(trial group) or chemoradiotherapy alone(control group) with 3 weeks as one course of treatment.The efficacy and toxicity of the two groups after 2 courses of treatment were evaluated.RESULTS:The response rate of the trial group vs.control group was 70.5% vs.59.1%(P<0.05).The toxic reactions such as radiation esophagitis,hepatic and renal lesions,digestive tract reaction,arrest of bone marrow in the control group was more severe than in the trial group(P<0.05).CONCLUSION:Compound glycyrrhizin and chemoradiotherapy used concomitantly showed a satisfactory efficacy and less toxic and side effects for advanced esophageal carcinoma.