A new synthesis of Rink's polymer, 4-(2′,4′-dimethoxyphenylhydroxymethyl) phenoxymethylpolystyrene |
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Authors: | GY
RGYI V RADI,G BOR K. T
TH,BOTOND PENKE |
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Affiliation: | GYÖRGYI VÁRADI,GÁBOR K. TÓTH,BOTOND PENKE |
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Abstract: | For solid-phase peptide synthesis, 2, 4-dimethoxy-4′ -hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2, 4-dimethoxy-4′-hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution. |
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Keywords: | 2,4-dimethoxy-4′ -hydroxybenzhydrol potassium salt coupling of phenolate side reactions substitution level |
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