Analysis of Risk Factors for Ventilator-Associated Pneumonia in a Multidisciplinary Intensive Care Unit |
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| Authors: | D C Sofianou T C Constandinidis M Yannacou H Anastasiou E Sofianos |
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| Institution: | (1) Department of Medical Microbiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR;(2) Department of Hygiene and Epidemiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR;(3) Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR |
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| Abstract: | A prospective study was conducted to determine the incidence, risk factors and pathogens of ventilator-associated pneumonia
(VAP) in 198 patients requiring mechanical ventilation for more than 48 hours. VAP occurred in 67 (33.8%) patients. Risk factors
associated with VAP were admission APACHE II score >20 (odds ratio OR] 4.77, 95% confidence interval CI] 2.04–11.27, P<0.001), mechanical ventilation >10 days (OR 44.4, 95% CI 2.16–26.7, P<0.0001), ICU length of stay >10 days (OR 9.4, 95% CI 3.55–25.65, P<0.0001), and admission PaO2/FiO2 ratio <200 mmHg (OR 3.4, 95% CI 1.00–11.41, P<0.05). Logistic regression analysis showed a relationship between VAP and length of stay in ICU, duration of fever and presence
of catheter-related infection. The pathogens isolated were predominantly gram-negative bacteria (83.2%), with a high proportion
of Acinetobacter spp. (35%) resistant to commonly used antimicrobial agents. The mortality rate was not influenced by VAP. |
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