Fas/FasL系统介导的细胞凋亡与卵泡闭锁及稽留流产的关系

Fas/FasL是细胞表面的两种跨膜蛋白。目前研究认为FasL是死亡因子,Fas则是其受体。当一个细胞的FasL与另一个细胞的Fas结合时,可以导致表达Fas的细胞凋亡。Fas又称Apo-1,即CD95分子。人Fas基因定位于10号染色体q23,基因长度约25Kb。人FasL基因定位于1号染色体q23,基因长度约8Kb。Fas/FasL系统与卵泡闭锁生理过程、自身免疫疾病、肿瘤发生、移植物耐受等均有密切关系。近年来细胞凋亡因素导致稽留流产的发生受到人们的关注,而其中Fas/FasL系统在促进绒毛组织细胞凋亡方面占据重要的地位。

The relationship between apoptosis,atresia folliculi and missed abortion mediated by Fas/FasL system

Fas/FasL were two kinds of transmembrane protein on the cell surface.The current study showed that FasL was the death factor and Fas was its receptor.When the FasL of a cell combined with the Fas of another,they could lead that the cell which expressed Fas died.Fas was named Apo-1,meaning CD95.Fas gene was located on human q23 of the chromosome 10 and the gene length was about 25 Kb.FasL gene was located on human q23 of the chromosome 1 and the gene length was about 8Kb.The Fas/FasL system was closely related to Physiological process of follicular atresia,autoimmune diseases,tumors and graft tolerance.Recently the incidence of missed abortion related to apoptosis has been attended by people and the Fas/FasL system is important in promoting apoptosis.