| 铁死亡机制在视网膜色素上皮细胞损伤相关眼病中的研究进展 |
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| 引用本文： | 王巧云,解来青. 铁死亡机制在视网膜色素上皮细胞损伤相关眼病中的研究进展[J]. 国际眼科杂志, 2023, 23(1): 75-78 |
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| 作者姓名： | 王巧云 解来青 |
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| 作者单位： | 中国江苏省苏州市,苏州大学附属第二医院眼科,中国江苏省苏州市,苏州大学附属第二医院眼科 |
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| 基金项目： | 江苏省卫生健康委医学科研项目(No.M2020053); 苏州市医疗卫生科技创新(应用基础研究)项目(No.SKJY2021083) |
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| 摘 要： | 铁死亡(ferroptosis)是一种新发现的以脂质过氧化和铁积累为特征的程序性细胞死亡。近年来，随着铁死亡概念的提出和其机制研究的不断深入，视网膜色素上皮细胞(retinal pigment epithelium cells, RPECs)功能下降相关眼病如年龄相关性黄斑变性(age-related macular degeneration, AMD)、视网膜色素变性(retinitis pigmentosa, RP)和糖尿病视网膜病变(diabetic retinopathy, DR)等疾病的发病机制的探索也取得了重大突破。本文将对铁死亡的基本概念、RPECs铁死亡的主要机制及调控铁死亡对RPECs相关眼病发生发展的作用研究进行综述，希望为RPECs相关眼病发病机制的研究提供参考。
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| 关 键 词： | 铁死亡 视网膜色素上皮细胞 眼病 |
| 收稿时间： | 2022-05-31 |
| 修稿时间： | 2022-12-02 |
Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
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| Qiao-Yun Wang and Lai-Qing Xie. Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury[J]. International Eye Science, 2023, 23(1): 75-78 |
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| Authors: | Qiao-Yun Wang and Lai-Qing Xie |
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| Affiliation: | Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China and Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China |
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| Abstract: | Ferroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathogenesis of ocular diseases related to the function decline of retinal pigment epithelium cells(RPECs), such as age-related macular degeneration(AMD), retinitis pigmentosa(RP)and diabetic retinopathy(DR). This article reviews the basic concept of ferroptosis, the main mechanism of ferroptosis in RPECs and the role of ferroptosis regulation in the development of RPECs-related ocular diseases, hoping to provide references for the study of the pathogenesis of RPECs-related ocular diseases. |
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| Keywords: | ferroptosis retinal pigment epithelial cells ocular disease |
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