玉屏风散联合化学药喷雾治疗支气管哮喘的系统评价

目的 系统评价玉屏风散联合化学药喷雾治疗支气管哮喘的有效性及安全性。方法 计算机检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、中国生物医学文献数据库（SinoMed）、维普生物医学数据库（VIP）、PubMed、Cochrane Library、Embase、Web of Science数据库中玉屏风散（颗粒）联合化学药喷雾治疗支气管哮喘的随机对照试验（RCT），检索时限为从建库至2022年9月1日。由2名研究人员独立检索、筛选文献、提取数据、纳入符合标准的文献，参照Cochrane风险偏倚评价工具进行文献质量评估，使用RevMan 5.4软件进行Meta分析。结果 共纳入12项RCTs，包括1190例患者。Meta分析结果显示，玉屏风散（颗粒）联合化学药喷雾（试验组）治疗支气管哮喘的总有效率明显优于单纯使用化学药喷雾（对照组）［OR=3.41，95%CI（2.35，4.96），P＜0.00001］；试验组可有效控制哮喘症状［MD=3.59，95%CI（2.12，5.06），P＜0.00001］，明显改善肺功能指标［1秒用力呼气容积（FEV1）、呼气流量峰值（PEF）等］，FEV1［MD=0.57，95%CI（0.43，0.71），P＜0.0001］、PEF［MD=0.66，95%CI（0.40，0.92），P＜0.00001］。结论 玉屏风散（颗粒）联合化学药喷雾治疗支气管哮喘，疗效显著且安全性较高，适于临床应用。

Systematic evaluation of Yupingfeng Powder combined with chemical spray in treatment of bronchial asthma

Objective To systematically evaluate the efficacy and safety of Yupingfeng Powder combined with chemical spray for bronchial asthma. Methods Data were electronically searched from CNKI, Wanfang Data, SinoMed, VIP, PubMed, Cochrane Library Embase, and Web of Science, from the date of establishment to September 1, 2022, for the randomized controlled trial (RCT) of Yupingfeng Powder combined with chemical spray in treatment of bronchial asthma. Two researchers dependently searched, screened, extracted data and included the documents that met the standards. The literature quality was evaluated with reference to Cochrane risk bias evaluation tool, and the data was analyzed with RevMan 5.4 software. Results A total of 12 RCTs involving 1190 patients were included. Meta-analysis showed that the total effective rate of treating bronchial asthma with Yupingfeng Powder combined with chemical spray (experimental group) was significantly better than that with conventional western medicine (control group) OR = 3.41, 95%CI (2.35, 4.96), P<0.00001], which can effectively control asthma symptoms MD = 3.59, 95%CI (2.12, 5.06), P<0.00001], the lung function indexes forced expiratory volume in one second (FEV1), peak expiratory flow (PEF)] were significantly improved, FEV1 MD = 0.57, 95%CI (0.43, 0.71), P<0.0001], PEF MD = 0.66, 95%CI (0.40, 0.92), P<0.00001]. Conclusions Yupingfeng Powder combined with chemical spray is effective and safe for bronchial asthma, which has evidence-based basis and issuitable for clinical application.