环状RNA在肿瘤非手术治疗中的研究进展

肿瘤是机体细胞异常增生形成的一类疾病，具有占位、侵袭、转移、消耗等特性，可严重损害人类脏器的结构与功能，对人类健康与发展形成严重威胁。目前针对肿瘤的治疗手段主要有手术治疗与非手术治疗，其中手术治疗对肿瘤大小、部位、转移情况及患者耐受程度有一定的要求，并对已有多部位转移或基础条件较差的肿瘤患者具有一定的局限性，而非手术治疗可很好地弥补这一不足。当前针对肿瘤的非手术治疗主要为放射治疗、化学治疗、免疫治疗、靶向治疗及中医治疗等几种方式，但因肿瘤细胞的抵抗性和耐受性，使得治疗效果大打折扣，因此，进一步探明其具体机制以提高治疗效果显得尤为迫切。环状RNA有望成为一个重要突破口，它凭借自身的特殊结构，在多种肿瘤中能够稳定且有差异表达。本文综述与总结环状RNA在多种肿瘤非手术治疗中的研究进展，希望能为肿瘤治疗提供新思路。

Clinical study of drospirenone ethinyl estradiol in the treatment of adenomyosis

Objective To observe the clinical efficacy and safety of drospirenone and ethinylestradiol in the treatment of adenomyosis after operation. Methods A total of 109 patients admitted to Lanxi People''s Hospital after conservative treatment for adenomyosis from February 2019 to February 2021 were selected and divided into the control group (n=55) and the test group (n=54) using the random number table method. Patients in both groups received routine treatment with levonorgestrel intrauterine sustained release system 3-7 days after menstruation, and patients in experimental group received drospirone and ethinylestradiol on the basis of routine treatment. The degree of dysmenorrhea, menstrual volume, carbohydrate antigen 125 (CA125) level, recurrence risk within 1 year and incidence of adverse reactions were compared between the two groups before treatment and 3, 6 and 12 months after treatment. Results The degree of dysmenorrhea, menstrual volume and CA125 level in the two groups at 3, 6 and 12 months after treatment were decreased compared with those before treatment, and the patients in the experimental group were significantly lighter than those in the control group (P<0.05). The recurrence risk of adenomyosis, irregular bleeding and the proportion of intrauterine sustained release system in the experimental group within 1 year were significantly lower than those in the control group (P<0.05). There was no significant difference in the proportion of patients with mild breast pain and ovarian functional cyst (P>0.05). Conclusion Drospirenone ethinylestradiol tablets can effectively reduce the menstrual volume of patients with adenomyosis after surgery, reduce the degree of dysmenorrhea, effectively prevent the recurrence of adenomyosis, and have fewer adverse reactions.