中药制剂掩味用包衣材料的研究进展

中药口服制剂多为复杂体系，口感较差，影响着患者服药的依从性，因此对其进行口感改良具有现实意义。矫掩味方法多样，其中包衣法较为常用，包衣层可减少药物与苦味受体的接触，从而达到掩味的目的。采用包衣法掩味时，除需保证良好的掩味效果外还需保证药物的释放，包衣材料的选择至关重要。中药制剂常用的包衣材料主要包括糖类如壳聚糖、环糊精、纤维素衍生物等，树脂类如丙烯酸树脂等，脂类如巴西棕榈蜡、山嵛酸甘油酯等。对常用的掩味用包衣辅料进行了综述，以期能为中药掩味包衣材料的选择提供参考。

Research progress on taste-masking coating materials for traditional Chinese medicine preparations

Most of the oral preparations of Chinese medicine are complex systems and have poor taste, which affects patients'' compliance of taking medicine. Therefore, improving the taste has practical significance. There are various taste masking methods, among which, the coating method is commonly used. The coating layer can reduce the contact between the drug and the bitter receptor, so as to achieve the purpose of taste masking. When using coating method to mask taste, the release of drug should be guaranteed in addition to the good taste masking effect. Therefore, the selection of coating material is crucial. Commonly used coating materials mainly include sugars such as chitosan, cyclodextrin, cellulose derivatives, resins such as acrylic resin, and lipids such as carnauba wax and behenate glyceride. In this paper, the commonly used taste-masking coating excipients were reviewed in order to provide reference for the selection of taste-masking coating materials for chinese medicine.