血清淀粉样蛋白A在急性主动脉夹层中的研究进展

急性主动脉夹层(AAD)是一种非常凶险的心血管急症，尽管目前在诊断和救治方面取得了一定进展，但AAD的死亡率仍居高不下。由于AAD是一种多因素参与的疾病，参与其发病的病理生理学机制尚未完全阐述清楚，因此其临床治疗效果有限，死亡率极高。大量研究表明，血清淀粉样蛋白A(SAA)作为急性期反应产生的主要炎症蛋白，与心血管疾病的发生发展密切相关。因此，SAA或可成为AAD诊断和治疗的候选靶点。本综述探讨了SAA与炎症反应、血管功能异常、血栓形成、细胞外基质重塑之间的关系以及作为AAD潜在生物标志物的可能性。

Research progress of serum amyloid A in acute aortic dissection

Acute aortic dissection (AAD) is a very dangerous cardiovascular emergency. Although some progress has been made in diagnosis and treatment, the mortality rate of AAD is still high. AAD is a multi-factor involved disease, and its pathophysiological mechanism has not been fully explained, so its clinical treatment effect is limited and its mortality rate is extremely high. A large number of studies have shown that serum amyloid A (SAA), as a major inflammatory protein produced in the acute phase response, is closely related to the occurrence and development of cardiovascular diseases.Therefore, SAA may become a candidate target for the diagnosis and treatment of AAD. This review discusses the relationship between SAA and inflammatory response, vascular dysfunction, thrombosis and extracellular matrix remodeling, and the possibility of SAA as a potential biomarker of AAD.