富含Gla蛋白参与冠状动脉钙化机制的研究进展

冠状动脉钙化在冠状动脉粥样硬化性心脏病患者中较为常见，目前对其发生、发展及形成机制尚不清楚。富含Gla蛋白(GRP)是新近发现的维生素K依赖性蛋白，研究表明GRP通过与矿物质结合发挥抑制钙化晶体的形成及成熟、参与基质Gla蛋白-胎球蛋白A钙化的抑制途径、阻断钙化诱导剂的信号通路及抗炎作用，起到抑制血管钙化的作用。本文就GRP参与冠状动脉钙化机制的研究进展进行综述，为冠状动脉钙化的预防、治疗提供新的方向。

Research progress on the mechanism of Gla-rich protein involvement in coronary artery calcification

Coronary artery calcification is commonly seen in patients with coronary atherosclerotic heart disease, but the mechanism of its happening, development, and formation is less known. Gla-rich protein (GRP) is a newly discovered vitamin K-dependent protein. Studies have shown that GRP inhibits the formation and maturation of calcified crystals by binding to minerals, participates in the inhibition pathway of matrix Gla protein-fetuin-A calcification, blocks the signalling pathway of calcification inducers and has an anti-inflammatory effect, thus playing a role in inhibiting vascular calcification. In this paper, the research progress of GRP''s participation in the mechanism of coronary artery calcification will be conducted in the hope of providing a new direction for the prevention and treatment of coronary artery calcification.