Micro-RNA在变应性鼻炎中的作用及其研究进展

变应性鼻炎(AR)是发生在鼻黏膜的变态反应性疾病，其特征是与血清IgE水平升高相关的辅助型T细胞2(Th2)主导的免疫反应。它不同程度影响个人社会生活、睡眠和工作，并可增加家庭和社会经济负担。目前AR的治疗在免疫疗法、鼻内类固醇、抗组胺药和肥大细胞稳定剂等方面取得了有效进展，但20%的AR患者并未表现出足够的主观和客观改善。因此，深入研究AR的发病机制，并开发用于治疗AR的新型制剂已是当务之急。Micro-RNA(miRNA)是一种基因表达调控小分子RNA,被认为与许多炎症性疾病有关，已经逐渐成为国内外学者研究的重点。本文系统综述了与AR密切相关的miRNA,并对研究现状做了简要评析，指出了当前亟待深入研究的问题，希望能对该领域的发展提供一定的参考。

Role and research progress of micro-RNA in allergic rhinitis

Allergic rhinitis (AR) is an allergic disease of the nasal mucosa, which is characterized by an immune response dominated by helper T cell 2 (Th2) associated with elevated serum IgE levels. It greatly affects the social life, sleep and work of individuals. AR increases the burden of family and social economy. At present, effective progress has been made in the treatment of AR in immunotherapy, intranasal steroids and antihistamines, and mast cell stabilizers. However, 20% of AR patients did not show sufficient subjective and objective improvement. Therefore, it is urgent to further study the pathogenesis of AR and develop new preparations for the treatment of AR. Micro-RNA (miRNA) is a kind of small molecule RNA regulating gene expression, which is believed to be related to many inflammatory diseases. It has gradually become the focus of research by scholars at home and abroad. In this paper, AR-related micro-RNA was systematically summarized, and the current research of AR was briefly reviewed. This paper hopes to provide some references for the development of this field, which has pointed out the problems that need to be further studied in AR.