骨髓、脾脏FDG摄取水平与非小细胞肺癌临床病理特征

目的 观察¹⁸F-FDG PET/CT所示骨髓及脾脏FDG摄取水平与非小细胞肺癌(NSCLC)患者临床病理特征的关系。方法 纳入82例术前接受¹⁸F-FDG PET/CT检查的NSCLC患者(NSCLC组)及41例非肿瘤患者(对照组),比较2组骨髓、脾脏FDG摄取水平差异，观察其与临床病理特征之间的关系。结果 NSCLC组骨髓平均标准摄取值(SUV_mean)、骨髓SUV_mean与肝脏SUV_mean比值(BLR),以及脾脏SUV_mean与肝脏SUV_mean比值(SLR)均高于对照组(P均<0.05)。男性患者、鳞癌、高TNM分期、肿瘤>3 cm及伴局部淋巴结转移者NSCLC原发灶的最大标准摄取值(SUV_max)更高(P均<0.05);高TNM分期、肿瘤>3 cm及伴局部淋巴结转移患者骨髓SUV_mean及BLR更高(P均<0.05);高TNM分期及肿瘤>3 c...

FDG uptake level of bone marrow and spleen with clinicopathological features in non-small cell lung cancer patients

Objective To explore the relationships of FDG uptake level of bone marrow and spleen on ¹⁸F-FDG PET/CT with clinicopathological features in patients with non-small cell lung cancer (NSCLC). Methods Totally 82 NSCLC patients who underwent preoperative ¹⁸F-FDG PET/CT examination (NSCLC group) and 41 non-tumor patients (control group) were enrolled. The levels of FDG uptake in bone marrow and spleen were compared between groups, and the relationships of FDG uptake and clinicopathological features were analyzed. Results The mean standard uptake value (SUV_mean) of bone marrow, bone marrow to liver uptake ratio (BLR), as well as spleen to liver uptake ratio (SLR) in NSCLC group were all higher than those in control group (all P<0.05). NSCLC patients who were male, with squamous cell carcinoma, high TNM stage, tumor size >3 cm and local lymph node metastases had higher primary focus maximum standard uptake value (SUV_max) (all P<0.05). Patients with higher TNM stage, tumor size >3 cm and local lymph node metastases had higher bone marrow SUV_mean and BLR (all P<0.05), with higher TNM stage and tumor size >3 cm had higher SLR (both P<0.05). Splenic SUV_mean was only associated with TNM stage (P<0.05). Conclusion High FDG uptake of bone marrow and spleen in NSCLC patients were related to the clinicopathological features of tumor reflecting poor prognosis.