1990-2019年中国早产患病率及疾病负担变化趋势研究题录

目的描述1990-2019年中国早产患病率及疾病负担变化趋势。方法数据来源于2019年全球疾病负担数据库, 采用早产患病率(%)和伤残调整寿命年(DALYs)率, 分性别评估早产的患病和疾病负担分布情况, 并将中国、全球及世界银行定义的高收入、中高收入、中低收入和低收入国家的平均早产患病率和DALYs率进行对比。采用Joinpoint对数线性回归模型检验变化趋势。结果 2019年我国早产患病率为6.34%95%不确定区间(UI):6.23%～6.44%], 低于全球平均水平(11.24%, 95%UI:11.16%～11.32%)及低收入(13.15%, 95%UI:12.97%～13.33%)、中低收入(12.53%, 95%UI:12.39%～12.68%)、中高收入(8.22%, 95%UI:8.15%～8.29%)、高收入(8.75%, 95%UI:8.67%～8.84%)国家平均水平;早产DALYs率(人年/10万)为217.12(95%UI:191.30～246.69), 低于全球(886.81, 95%UI:762.12～1 034.49)、低收入(1 905.24, ...

Prevalence and disease burden of preterm birth in China from 1990 to 2019

Objective To depict the long-term trends of prevalence and disease burden of preterm birth from 1990 to 2019. Methods Data was from the 2019 Global Burden of Disease study. The prevalence rate (%) and disability adjusted life years (DALYs) rate of preterm birth were adopted and were further stratified by sex. China''s prevalence rate and DALYs rate were compared with those of high-income, middle and high-income, middle and low-income, and low-income countries, defined by the World Bank. Joinpoint log-linear regression model was used to analyze the trend. Results In 2019, the prevalence of preterm birth in China was 6.34%95% uncertainty interval (UI):6.23%-6.44%], lower than the global average level (11.24%,95%UI:11.16%-11.32%) or the average level of low-income (13.15%, 95%UI:12.97%-13.33%), lower-middle income (12.53%, 95%UI:12.39%-12.68%), upper-middle income (8.22%, 95%UI:8.15%-8.29%) and high-income (8.75%, 95%UI:8.67%-8.84%) countries. The DALYs rate (person-year/100 000) of preterm birth in China was 217.12 (95%UI:191.30-246.69), lower than the average level of the world (886.81, 95%UI:762.12-1 034.49), low-income (1 905.24, 95%UI:1 542.35-2 377.54), lower-middle-income (1 349.98, 95%UI:1 154.04-1 583.81) and upper-middle-income (366.56, 95%UI:321.51-416.88) countries, but higher than the average level of high-income countries (206.21,95%UI:179.96-234.90). From 1990 to 2019, the prevalence and DALYs rate of preterm birth in China showed a downward trend, with an average annual decline of 0.56% (95%CI:0.54%-0.58%) and 5.87% (95%CI:5.54%-6.19%), respectively. In general, the prevalence rate of preterm birth in men declined faster than that in women (men:0.64%, 95%CI:0.62%-0.66%; women:0.46%, 95%CI:0.44%-0.48%), so as the DALYs rate (men:5.90%, 95%CI:5.56%-6.24%; women:5.81%,95%CI:5.50%-6.13%). Conclusions From 1990 to 2019, the prevalence and DALYs rate of preterm birth in China showed an overall downward trend, and the decline rate was higher in men than in women. The etiological research on the risk factors of preterm birth, especially spontaneous preterm birth, should be further pursued, and a more comprehensive and precise monitoring, prevention, and health care system for preterm birth needs to be formulated.