| 微重力对细胞衰老影响的研究进展 |
| |
| 引用本文： | 吕文君,宋关斌,罗 庆. 微重力对细胞衰老影响的研究进展[J]. 医用生物力学, 2023, 38(1): 189-194 |
| |
| 作者姓名： | 吕文君 宋关斌 罗 庆 |
| |
| 作者单位： | 重庆大学 生物工程学院,生物流变科学与技术教育部重点实验室 |
| |
| 基金项目： | 中国载人航天工程国际合作项目,重庆市自然科学基金项目( cstc2020jcyj-msxmX0539),中央高校基本科研业务费项目( 2020CDJLHZZ-028),重庆市教育委员会干细胞生物力学研究生导师团队项目(ydstd1823) |
| |
| 摘 要： | 微重力是太空环境的典型特征。大量的太空飞行以及地基模拟实验显示，在微重力/模拟微重力效应刺激下细胞展现出细胞增殖减少和细胞周期停滞等衰老的典型生物学特征，但微重力/模拟微重力效应影响细胞衰老的分子机制尚不十分清楚。加深对微重力环境影响细胞衰老机制的认识有助于探索太空微重力环境下的抗衰老策略和靶向干预手段。近年来，国内外学者在微重力/模拟微重力效应对细胞衰老的影响和相关机制方面开展了较多的研究探索，本文就相关研究进展进行综述。
|
| 关 键 词： | 微重力 模拟微重力效应 细胞衰老 信号通路 |
| 收稿时间： | 2021-12-31 |
| 修稿时间： | 2022-02-09 |
Research Progress of the Effect of Microgravity on Cellular Senescence |
| |
| Affiliation: | Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering,Chongqing University |
| |
| Abstract: | Microgravity is a typical feature of the space. A large number of space flights and foundation simulation experiments have shown that cells show typical biological characteristics of aging, such as reduced cell proliferation and cell cycle arrest under microgravity or simulated microgravity. However, the molecular mechanism by which microgravity or simulated microgravity affects cellular senescence is not well understood. Understanding the mechanism controlling cellular senescence induced by microgravity environment is helpful for exploring anti-aging strategies and targeted interventions in space. In recent years, domestic and foreign scholars have carried out a number of researches and explorations on the effect of microgravity and simulated microgravity on cellular senescence as well as the related mechanisms. In this review, the latest research progress of this filed was summarized. |
| |
| Keywords: | microgravity simulated microgravity effect cellular senescence signaling pathways |
|
| 点击此处可从《医用生物力学》浏览原始摘要信息 |
|
点击此处可从《医用生物力学》下载全文 |
