Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous components: a case report |
| |
Authors: | Taishi Fujii Takuma Arai Masahiro Sakon Shinji Sawano Yoshitaka Momose Keiko Ishii Shiro Miwa |
| |
Affiliation: | 1.Department of Surgery, Okaya Municipal Hospital, Hon-machi 4-11-33, Okaya, 394-8512, Japan;2.Department of Pathology, Okaya Municipal Hospital, Hon-machi 4-11-33, Okaya, 394-8512, Japan |
| |
Abstract: | We report a rare case of recurrent retroperitoneal dedifferentiated liposarcoma with osteosarcomatous components. An 82-year-old male diagnosed with recurrent retroperitoneal liposarcoma underwent a tumor resection. Histologically, osseous matrix with osteoid and mature hyaline cartilaginous tissues with high cellularity were observed in a fibrous background through most of the tumor, and scattered MDM2- and CDK4-positive atypical hyperchromatic stromal cells were detected surrounding the dedifferentiated areas. Dedifferentiation occurs in up to 10% of well-differentiated liposarcomas, frequently resembling a malignant fibrous histiocytoma-like pleomorphic sarcoma. In contrast, divergent differentiation with osteosarcomatous components is considered to be extremely rare. |
| |
Keywords: | Dedifferentiated liposarcoma osteosarcoma retroperitoneum |
|
|