抗真菌药物联合治疗侵袭性真菌感染的研究进展

近些年,侵袭性真菌感染的发病率逐年增加。由于临床上单药治疗侵袭性真菌感染的效果欠佳,特别是耐药真菌的感染,可选择的药物极少,导致相关疾病的发病率和死亡率仍很高,故抗真菌药物的联合治疗得到了广大学者的青睐。总结了抗真菌药物联合治疗侵袭性真菌感染的机制,综述了针对中枢神经系统、肺部、血液系统、其他部位侵袭性真菌感染的联合用药情况,为临床合理使用抗菌药物提供参考依据。

Advances in treatment of invasive fungal infection with combination therapy of antifungal drugs

In recent years, the incidence of invasive fungal infection has been increasing year by year. Due to the poor clinical efficacy of single drug in treatment for invasive fungal infections, especially for drug-resistant fungal infections, and few drugs to choose, it had led to a high incidence rate and mortality rate of related diseases. Therefore, combination therapy of antifungal drugs has been favored by many scholars. This article summarized treatment mechanism of the combined use of antifungal drugs against invasive fungal infections, and reviewed the combined use of drugs against invasive fungal infections in the central nervous system, lung, blood system, and other parts, providing a reference for the rational use of antibiotics in clinical practice.