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| 地夸磷索钠联合强脉冲光治疗角膜屈光手术后睑板腺功能障碍性干眼 | |
| 引用本文： | 张美美,王燊,张晶,李辰,盖珊珊,于嘉,周跃华.地夸磷索钠联合强脉冲光治疗角膜屈光手术后睑板腺功能障碍性干眼[J].国际眼科杂志,2023,23(2):198-202. |
| 作者姓名： | 张美美 王燊 张晶 李辰 盖珊珊 于嘉 周跃华 |
| 作者单位： | 中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科,中国北京市,北京茗视光眼科,中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科,中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科,中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科,中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科,中国四川省成都市,成都中医药大学眼科学院; 中国北京市,北京茗视光眼科 |
| 摘 要： | 目的:观察地夸磷索钠联合强脉冲光(IPL)对屈光术后睑板腺功能障碍(MGD)性干眼的治疗效果。方法:选取2021-03/12在本院进行激光角膜屈光手术后6mo内确诊的MGD性干眼患者64例128眼。随机分为对照组和试验组，对照组患者33例66眼接受玻璃酸钠联合IPL治疗，试验组患者31例62眼接受地夸磷索钠联合IPL治疗。两组患者每次IPL治疗前均进行眼部症状评分，检查非接触式泪膜破裂时间(NIBUT)、泪河高度、泪膜脂质层分级、睑板腺缺失率及裸眼视力。结果:IPL治疗后，两组患者眼部症状评分、睑板腺缺失率评分均持续降低，NIBUT、泪河高度、泪膜脂质层分级均持续升高，裸眼视力无明显变化，且第3次IPL治疗前试验组患者NIBUT优于对照组(6.24±0.27s vs 5.51±0.24s,P=0.046)。结论:地夸磷索钠和玻璃酸钠联合IPL均对MGD性干眼有较好的治疗效果，但短期内疗效差异不显著。 |
| 关 键 词： | 地夸磷索钠 强脉冲光 角膜屈光手术 睑板腺功能障碍 干眼 |
| 收稿时间： | 2022/5/7 0:00:00 |
| 修稿时间： | 2023/1/18 0:00:00 |
Diquafosol sodium combined with intense pulsed light in the treatment of meibomian gland dysfunction dry eye after corneal refractive surgery |
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| Mei-Mei Zhang,Shen Wang,Jing Zhang,Chen Li,Shan-Shan Ge,Jia Yu and Yue-Hua Zhou.Diquafosol sodium combined with intense pulsed light in the treatment of meibomian gland dysfunction dry eye after corneal refractive surgery[J].International Journal of Ophthalmology,2023,23(2):198-202. | |
| Authors: | Mei-Mei Zhang Shen Wang Jing Zhang Chen Li Shan-Shan Ge Jia Yu and Yue-Hua Zhou |
| Institution: | Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China,Ophthalmology Beijing Ming Vision, Beijing 110000, China,Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China,Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China,Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China,Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China and Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 510100, Sichuan Province, China; Ophthalmology Beijing Ming Vision, Beijing 110000, China |
| Abstract: | AIM: To observe the therapeutic effect of the diquafosol sodium combined with intense pulsed light(IPL)on meibomian gland dysfunction(MGD)dry eye after refractive surgery. METHODS:A total of 64 patients(128 eyes)with MGD dry eye diagnosed within 6mo after laser corneal refractive surgery in our hospital from March 2021 to December 2021 were selected. They were randomly divided into control group and experimental group. A total of 33 patients(66 eyes)in the control group were treated with sodium hyaluronate combined with IPL, and 31 patients(62 eyes)in the experimental group were treated with diquafosol sodium combined with IPL. Ocular symptom scores were performed before each IPL treatment in both groups to examine non-invasive tear breakup time(NIBUT), tear meniscus height, lipid layer grade of tear film, meibomian gland deletion rate and uncorrected visual acuity. RESULTS:After IPL treatment, ocular symptom scores and meibomian gland deletion rate score of two groups were decreased continuously. NIBUT, tear meniscus height and lipid layer grade of tear film were increased continuously, and there was no significant change in uncorrected visual acuity. NIBUT of patients in the experimental group was better than that in the control group before the third IPL treatment(6.24±0.27s vs. 5.51±0.24s, P=0.046). CONCLUSIONS:Both diquafosol sodium and sodium hyaluronate combined with IPL showed good therapeutic effect on MGD dry eye, but there was no significant difference in the short-term efficacy between the two groups. |
| Keywords: | diquafosol sodium intense pulsed light corneal refractive surgery meibomian gland dysfunction dry eye |
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