代谢重编程在电离辐射及其旁效应中的研究进展

代谢重编程是指肿瘤细胞为满足自身生长和能量的需求, 通过改变代谢模式来调节细胞生物学功能, 帮助自身抵御外界胁迫, 从而使细胞适应低氧、酸性、营养物质缺乏等微环境而快速增殖的现象。放射生物学研究发现, 电离辐射可通过诱导细胞代谢重编程产生辐射抗性;也可通过旁效应促进未受照射细胞发生代谢重编程, 从而赋予细胞癌变和辐射抗性能力。因此, 探索电离辐射和电离辐射旁效应中代谢重编程机制, 可以为辐射防护、放射治疗、放射损伤诊断等提供新的思路和理论依据。本文对代谢重编程在电离辐射及其旁效应中的研究进展进行综述。

Research progress of the roles of metabolic reprogramming in radiation-induced direct- and bystander-effects

Metabolic reprogramming refers to the phenomenon that tumor cells, in order to meet their own growth and energy needs, regulate their biological functions by changing their metabolic mode, help themselves resist external stresses, and thus enable cells to adapt to hypoxia, acid, nutrient deficiency and other microenvironments and rapidly proliferate. It was found that metabolic reprogramming could contribute to radiation resistance and it also could be induced in bystander cells which may result in radiation resistance and the cancellation. Investigation the mechanism of radiation-induced metabolic reprogramming may provide new ideas and a theoretical framework for radiation protection, radiotherapy, and radio-diagnosis. This article reviewed the research progress on the mechanism of metabolic reprogramming in the direct and bystander effects of radiation.