晚期黄疸新生儿血液与母乳配对检测巨细胞病毒结果分析

目的:探讨晚期黄疸新生儿与母乳巨细胞病毒(CMV)感染的相关性。方法:应用荧光定量PCR法配对检测本院新生儿科2004年5月~2006年5月323例晚期黄疸患儿血和其母乳CMV-DNA含量,并检测血常规和肝功能,将结果进行对比分析。结果:①新生儿血阳性者104例,阳性率为32.2%;母乳阳性者254例,阳性率为78.6%。②和吸食阴性母乳者相比,吸食感染母乳的患儿更容易感染CMV(χ2=15.88,P<0.01)。③母乳CMV含量对患儿是否感染CMV没有显著性意义(t=1.028,P>0.05)。④早产儿较足月儿更容易感染CMV(χ2=9.29,P<0.01)。结论:母乳CMV感染可能是导致新生儿晚期黄疸的重要原因之一。

A case control study on cytomegalovirus infection of late jaundice newborns blood and breast milk

Objective:To investigate correlation between late neonatal jaundice and breast-milk-acquired cytomegalovirus infections.Methods:323 cases of children with late jaundice were selected form May 2004 to May 2006 in our hospital,and detected CMV-DNA in these infants blood and their maternal breast milk by fluorescent quantitation PCR.Blood routine examination was performed and their liver function was examined and outcome data were analyzed contrastively.Results:①Cytomegalovirus-seropositive newborns were 104 cases,the positive rate was 32.2 %;The positive rate of CMV-DNA of breast milk was 78.6%,cases were 254;②Compared to the breast milk noninfectious,newborns who via consumption of breast milk from cytomegalovirus-positive lactating mothers were more easily infected with CMV(χ2=15.88,P<0.01);③The copies of CMV-DNA in breast milk could not determine whether newborns being infected with CMV(t=1.028,P>0.05);④The premature infants were more easily infected with CMV than term infant(χ2=9.29,P<0.01).Conclusion:Breast-milk-acquired cytomegalovirus infections is a major cause of late neonatal jaundice in newborns.