结核患者肝功能检测的临床意义

目的探讨结核患者短期化疗所引起的肝损伤情况。方法516例结核患者检测其肝功能以及各型肝炎标志物。结果肝损害的发生率为16．3％，有基础性肝病与无肝炎病史的患者相比较，肝损害的发生率显著增高（X^2=22.73，P〈0．01），对肝细胞损害程度无显著性差异（t=0．05，P〉0．05）。60岁以上的老人化疗后肝损害的发生率明显高于60岁以下的人群（X^2=6．05，P〈0．01）。结论肺结核患者在化疗过程中，容易出现不同程度的肝损害，应密切检测其肝功能，防止发生严重的肝损害。

Clinical significance about detection of liver function in patients with tuberculosis

Objective To explore the influence of shorterm chemical trement to the drug-induced hepatitis.Methods Detected liver function and various types of hepatitis markers in 516 cases of tuberculosis patients.Results the rate of hepatic lesion was 16.3%. Significant differences were found in the rate of hepatic lesion(χ2=22.73,P＜0.01),but there were no differences about liver cell injury between a basis liver disease and patients without a history of hepatitis(t=0.05,P＞0.05).the rate of hepatic lesion among patients over 60 years was higher than that of patients less than 60 years after chemical trement.Conclusion Varying degrees of liver damage was found in tuberculosis patients during their chemotherapy process,liver function should be tested closely,prevent the occurrence of serious liver damage.