| 原发性膀胱移行细胞癌中P16基因缺失与突变及临床意义 |
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| 引用本文： | 邓远忠,谯体义,张科.原发性膀胱移行细胞癌中P16基因缺失与突变及临床意义[J].重庆医学,2000,29(1):8-10. |
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| 作者姓名： | 邓远忠 谯体义 张科 |
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| 作者单位： | 重庆医科大学附属第一医院!400016 |
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| 摘 要： | 目的：为探讨Ｐ１６基因的必变与膀胱移行细胞癌生物学行为的关系。方法：采用聚合酶链反应－单链构象多态性分析（ＰＣＲ－ＳＳＣＰ），对４０例膀胱移行细胞癌组织Ｐ１６基因纯合缺失、突变进行了研究。结果：膀胱移行细胞癌中Ｐ１６纯合缺失与突变率在Ⅰ、Ⅱ、Ⅲ级肿瘤中分别为７．１％、１８．８％、６０％。在Ｔｉｓ～Ｔ１期和Ｔ２～Ｔ４期分别为５．６％及４０．９％且与肿瘤细胞的分化程度、临床分期明显相关。结论：Ｐ１６基
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| 关 键 词： | 膀胱肿瘤 P16基因 移动细胞癌 基因突变 |
Homozygous Deletions and Mutations of P16 Gene in Transitional Cell Carcinoma of Bladder and Their Clinical Significance |
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| Deng Yuanzhong,Qiao Tiyi,Zhang Ke,et al..Homozygous Deletions and Mutations of P16 Gene in Transitional Cell Carcinoma of Bladder and Their Clinical Significance[J].Chongqing Medical Journal,2000,29(1):8-10. |
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| Authors: | Deng Yuanzhong Qiao Tiyi Zhang Ke |
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| Institution: | Deng Yuanzhong,Qiao Tiyi,Zhang
Ke,et al.
(Department of Urology,The College of Clinical Medicine,Chongqing University of Medical
Sciences, Chongqing,400016.) |
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| Abstract: | |
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| Keywords: | bladder neoplasms Carcinoma P16 gene Silver-staining PCR-SSCP |
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