尿路移行细胞癌患者黏膜组织中内皮素-1的表达及意义

目的探讨内皮素(ET)-1在尿路移行细胞癌(肾盂、输尿管、膀胱癌)患者中的表达及其临床意义.方法应用免疫组化SP法对30例尿路移行细胞癌及20例正常肾盂、输尿管、膀胱组织石蜡切片中ET-1的表达进行检测,结合临床资料进行分析.结果 ET-1在肿瘤组织中的表达阳性率为40.5%,明显高于正常组(P＜0.05).ET-1表达与尿路移行细胞癌组织学分级、临床分期相关(P＜0.05).结论 ET-1表达异常提示其可能参与尿路移行细胞癌的发生、发展与浸润,有望成为治疗人类尿路移行细胞癌的作用靶点.

Expression and significance of endothelin-1 in mucosa of urothelial transitional cell carcinoma

Objective To investigate the expression and significance of endothelin-1 ET-1 in urothelial transitional cell carcinoma. Methods Immunohistochemistry was applied to detect ET-1 expression in 30 cases of urothelial transitional cell carcinoma and 20 cases of normal urothelial transitional cell samples, the results were analyzed in combination with clinical data. Results ET-1 expression in urothelial transitional cell carcinoma was 40.5%, which was significantly higher than that in normal urothelial transitional cell samples(P ＜0.05). ET-1 expression was correlated with grade and stage of urothelial transitional cell carcinoma (P ＜0.05). Conclusion The over expression of ET-1 in urothelial transitional cell carcinoma tissues correlates closely with cancer genesis progression and invasiveness, suggesting that ET-1 might be a biomarker and as a therapeutic target in human urothelial transitional cell carcinoma.