乙型肝炎病毒前S1抗原检测的临床意义

目的研究乙型肝炎(以下简称乙肝)病毒前S1抗原检测的临床意义.方法用ELISA法对349例患者血清进行乙肝两对半、前S1抗原检测,其中138例患者还检测了HBV-DNA.结果 294例HBsAg( )中, 前S1抗原阳性率为60.9%;129例HBsAg( )、HBeAg( )标本中,前S1抗原阳性率为90.0%,165例HBsAg( )、HBeAg(-)标本中,前S1抗原阳性率为38.2%;在同时检测HBV-DNA与前S1抗原的138例的各种感染模式中,前S1抗原与HBV-DNA的阳性率也是比较吻合的.结论乙肝病毒前S1抗原可以反映HBV病毒的感染与复制,是乙型肝炎早期诊断、疗效评估的可靠指标,在临床上有着十分重要的意义.

Clinical significance of hepatitis B virus pre-S1 antigen

Objective To study the clincial significance of hepatitis B virus Pre-S1 antigen.Methods Pre-S1 antigen of 349 serums was detected by ELISA ,and HBV-DNA of 138 serums was tested by PCR at the same time.Results The positive rate of pre-Sl antigen was 60.9% in 294 cases of the HBsAg-positive group;the positive rate of pre-Sl antigen was 90.0% in 129 cases of the HBsAg -positive and HBeAg -positive group;the positive rate of pre-Sl antigen was 38.2% in 165 cases of the HBsAg -positive and HBeAg -negative group;the positive rate of Pre-Sl antigen and HBV-DNA was identical in 138 cases of different infections detected at the same time.Conclusion HBV pre-Sl antigen may reflect the replication and infection of hepatitis B virus,which can be used as a reliable marker of early diagnosis and the efficacy of therapy in hepatitis B,and have important significance in clinic.