| TRPV1与功能性胃肠病内脏高敏感关系研究进展 |
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| 引用本文： | 李姝,段丽萍. TRPV1与功能性胃肠病内脏高敏感关系研究进展[J]. 北京大学学报(医学版), 2011, 43(2): 311-314 |
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| 作者姓名： | 李姝 段丽萍 |
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| 作者单位： | （北京大学第三医院消化科，北京100191） |
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| 基金项目： | 国家高技术研究发展计划 |
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| 摘 要： | 功能性胃肠病(functional gastrointestinal disorders,FGIDs)是一组以腹痛、腹胀、恶心、呕吐、腹泻、便秘及排便困难等症状为临床表现,同时排除器质性病变的一类胃肠疾病综合征。FGIDs在普通人群的发生率达到34.6%[1],其症状的产生与多种生理、病生理改变有关,如胃肠动力异常、内脏感觉过
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| 关 键 词： | TRPV1 痛觉过敏 肠易激综合征 消化不良 |
| 收稿时间： | 2009-12-15 |
Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases |
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| LI Shu,DUAN Li-ping. Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases[J]. Journal of Peking University. Health sciences, 2011, 43(2): 311-314 |
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| Authors: | LI Shu DUAN Li-ping |
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| Affiliation: | LI Shu,DUAN Li-ping(Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China) |
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| Abstract: | Transient receptor potential vanilloid 1(TRPV1) is a nonselective cation channelwith high permeabili-ty for Ca2+.It may play a role in the development and maintenance of visceral pain and hypersensitivity states,which has generated a major interest in the development of specific vanilloid antagonists.In this review,a summary of the contribution of TRPV1 in the development of visceral hypersensitivity in functional dyspepsia and irritable bowel syndrome is presented with the structure,location,and related mo... |
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| Keywords: | TRPV1 |
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