Effect of prostacyclin on renal kallikrein release in man |
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| Authors: | A PIERUCCI B M SIMONETTI G CIABATTONI F TAGGI† S MORABITO S VASTANO F PUGLIESE |
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| Institution: | Department of Internal Medicine, Division of Nephrology, University of Rome 'La Sapienza';*Department of Pharmacology, Catholic University of Rome;†Laboratory of Epidemiology, and Biostatistics, National Institute of Health, Rome, Italy |
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| Abstract: | The aim of this research was to study exogenous prostacyclin effect on urinary kallikrein excretion (UKK) in man, to define whether prostacyclin-induced renin release and/or endogenously released cyclooxygenase products were responsible for prostacyclin-induced enhancement of UKK, to determine furosemide effect on UKK. Prostacyclin was infused in eight healthy men and repeated after propranolol and indomethacin treatment. Prostacyclin caused a dose-dependent increase of UKK. Pretreatment with propranolol and indomethacin did not affect prostacyclin-induced enhancement of UKK, although it reduced absolute values of plasma renin activity. Furosemide increased UKK and simultaneously urinary 6-keto-prostaglandin F1 alpha. We conclude that prostacyclin induces an increase in UKK in a dose-dependent manner; furosemide-induced renal prostacyclin synthesis is temporally related to enhancement of UKK; partial dissociation of UKK from plasma renin activity under propranolol and indomethacin treatment and in response to furosemide might suggest a direct effect of prostacyclin on UKK. |
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| Keywords: | Kallikrein prostacyclin renin |
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