| 亚甲基四氢叶酸还原酶基因C677T多态性与高尿酸血症相关 |
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| 引用本文： | 王芳,赵世华,阎胜利,王颜刚,李长贵.亚甲基四氢叶酸还原酶基因C677T多态性与高尿酸血症相关[J].中华内分泌代谢杂志,2007,23(1):62-63. |
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| 作者姓名： | 王芳 赵世华 阎胜利 王颜刚 李长贵 |
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| 作者单位： | 266003,青岛大学医学院附属医院内分泌科 |
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| 摘 要： | 采用PCR-RFLP方法检测高尿酸血症患者和正常对照者亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性,结果显示,山东沿海地区汉族人MTHFR基因C677T多态性与高尿酸血症相关,T等位基因是其危险因素,但与单纯高尿酸血症是否发展为痛风无关。
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| 关 键 词： | 高尿酸血症 痛风 亚甲基四氢叶酸还原酶 多态性 限制性片段长度 |
| 修稿时间： | 2005-07-20 |
Association of methylenetetrahydrofolate reductase gene C677T polymorphism with hyperuricemia |
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| WANG Fang,ZHAO Shi-hua,YAN Sheng-li,WANG Yan-gang,LI Chang-gui.Association of methylenetetrahydrofolate reductase gene C677T polymorphism with hyperuricemia[J].Chinese Journal of Endocrinology and Metabolism,2007,23(1):62-63. |
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| Authors: | WANG Fang ZHAO Shi-hua YAN Sheng-li WANG Yan-gang LI Chang-gui |
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| Institution: | Department of Endocrinology, Medical School Hospital of Qingdao University, Qingdao 266003, China |
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| Abstract: | The association of C677T polymorphism of methylenetertrahydrofolate reductase (MTHFR) gene with primary hyperuricemia and gout was observed in Han nationality at the coast of Shandong Province. MTHFR gene C677T polymorphism in 253 subjects was examined by PCR-RFLP. The results showed that MTHFR C677T polymorphism was associated with hyperuricemia, and the T allele was a risk factor. However, the polymorphism was not related to whether single hyperuricemia would develop into gout. |
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| Keywords: | Hyperuricemia Gout Methylenetetrahydrofolate reductase Polymorphism restriction fragment length |
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