慢性幽门螺杆菌感染与冠心病相关性的研究

目的探讨慢性幽门螺杆菌(HP)感染与冠心病的关系。方法用酶免疫检测法测定冠心病组(138例)和非冠心病组(95例)血清幽门螺杆菌抗体,确诊慢性幽门螺杆菌感染;同时用散射比浊法测定C-反应蛋白(CRP)、C3、C4及用血液凝固法测定纤维蛋白原(FIB)水平。结果①冠心病组血清HPIgG阳性率明显高于非冠心病组(44.2%和28.4%,P<0.05);②冠心病组中慢性HP感染者CRP、FIB、C3分别明显高于非HP感染者(P<0.001、P<0.001、P<0.01);③慢性幽门螺杆菌感染与高血压、糖尿病、肥胖、吸烟、年龄、性别及冠心病家族史无关。结论慢性HP感染与冠心病相关;HP感染可能通过促进CRP、C3、FIB水平而起作用。

The study of relationship between chronic helicobacter pylori infection and coronary heart disease

Objective To investigate the relations between chronic HP infection and coronary heart disease.Methods HPIgG(EIA)were measured in total 138 cases of CHD and 95 normal controls.C-reaction protein(CRP),fibrinogen(FIB),C3,C4 were measured in 138 cases of CHD.Results The rate of seropositive for HPIgG in CHD patients is significantly higher than that of controls(44.2% vs.28.4%,P<0.05),the level of CRP and FIB in these of HP IgG seropositivity are higher than that of HP seropositivity(P<0.001).The level of C3 in these cares is higher than that of controls(P<0.01).These was no correlation between chronic HP infection and hypertension,diabetes mellitus,fat,tobacco use,age,gender and family history.Conclusion There is relation between chronic HP infection and coronary heart disease.HP infection may act though raising the level of CRP,C3 and FIB.