不同用药方案治疗细菌性阴道病的近期疗效及成本-效果分析

目的:比较奥硝唑胶囊及乳杆菌活菌胶囊治疗细菌性阴道病(BV)的疗效及成本-效果。方法:将150例患者随机分成3组,分别口服奥硝唑胶囊(A组)、阴道内用乳杆菌活菌胶囊(B组)以及两药联用(C组)治疗BV,并运用药物经济学成本及成本-效果分析法进行评价。结果:A、B、C三组治愈率和总有效率分别为70.00%,60.00%、76.00%和88.00%、82.00%、96.00%,C组有效率明显高于B组(P<0.05),三组的成本-效果比分别为3.58、3.80和4.14,奥硝唑胶囊组的成本最低。结论:奥硝唑胶囊是治疗BV的首选方案,乳杆菌胶囊可作为一种替代性治疗药物,奥硝唑合并乳酸杆菌活菌胶囊可用于难治性BV治疗。

Analysis on the Effect and Cost-effectiveness in the Treatment of Bacterial Vaginosis with Defferent Administration

Objective:To evaluate the curative effect and cost-effectiveness in treatment of bacterial vaginosis(BV) with capsule of ornidazole and capsule of lactobacillus. Methods:150 cases of BV were randomly divided into three groups and treated with oral ornidazole capsule(group A),lactobacillus capsule for vagina(group B) and combined administration(group C) respectively.The cost-effectiveness of three strategies was analyzed and evaluated by pharmacoeconomics.Results: The cure rates and general response rates in the three groups were 70.00% in group A,60.00% in group B and 76.00% in group C.The general response rates in the three groups were 88.00 %,82.00 % and 96.00% respectively,the rate in group C is significantly higher than that in group B(P<0.05);The cost-effectiveness ratios of three groups were 3.58,3.80 and 4.14 respectively.The cost of ornidazole in the treatment of BV was the lowest among three groups.Conclusion:According pharmacoeconomic evaluation,ornidazole capsule is the first choice in treatment of BV.It is suggested that lactobacillus should be an alternative treatment if the patient affected by BV could not accept ornidazole.Combined administration should be used in the relapse cases.