肿瘤血管形成机理研究进展

肿瘤血管形成是非常活跃的领域，新进展层出不穷。本文仅就近几年血管形成机理方面的进展进行综述。主要进展包括：内皮细胞表面整合素表达及其调节通路上新的分子机理；调节VEGF／VEGFR通路的新分子机理；内皮细胞表面其他分子活化与血管形成；细胞代谢产物及一些细胞因子、黏附分子通过非常规途径影响内皮细胞迁移；非甾醇类抗炎药物、磺胺药、血管紧张素转化酶抑制剂等老药也在血管形成中扮演新角色；淋巴细胞、浆细胞、单核细胞等也在血管形成过程中发挥特殊作用。

Up-dated information on the mechanism of tumor angiogenesis

Tumor angiogenesis is an intensively engaged area and new improvements emerge everyday. This paper tried to review the advancement of the mechanisms of tumor angiogenesis. It mainly include new molecular mechanisms on integrin expression and regulation; new molecular mechanism on VEGF/VEGFR pathway; the activation of other molecules on endothelial cells; the influence of cellular metabolites and some growth factors on endothelial cell migration; the role of nonsteroidal anti-inflammatory drugs, sulfonamides and angiotension converting enzyme inhibitors in tumor angiogenesis; and also the special role of lymphocytes, mast cells and monocytes in tumor angiogenesis.