牛磺胆酸钠致大鼠急性出血坏死性胰腺炎早期胰腺血流的测定

作者以5％的牛磺胆酸钠(Na-Tc)注入大鼠胆胰导管内,引起急性出血坏死性胰腺炎,以注射生理盐水为实验对照组,测定血清脂肪酶和淀粉酶活性,结果注射Na-Tc后3小时此两酶的活性均显著升高,12小时最明显;用~(36)RbCl示踪法测定,显示胰腺血流量和胰组织灌流量于注射Na-Tc后1小时明显升高,并维持较高水平至12小时下降。这些结果提示:Na-Tc致大鼠急性出血坏死性胰腺炎早期胰腺血流量增加,为一般炎症充血反应。

Determination of Pancreatic Blood Flow at the Early Stage of Acute Haemorrhagic Necrotizing Pancreatitis Induced by Sodium Taurocholate in Rats

Acute haemorrhagic nec-rotizing pancreatitis was induced byinjecting 5% sodium taurocholate (Na-Tc)directly into the common iliopanreaticductin rats. In control group 0.9% NaClwas used. The activity of serum lipase andamylase distinctly increased at 3h andwent p to the maximum at 12 h afterinjection of Na-Tc. The pancreatic bloodflow and tissue perfsion per gram in-creased apparently at 1h and ecreased at12h ater injection of Na-Tc by using thefractional indicator distribution techniquewith ~(?)RbCl. The results demonstratedthat he eary stage of acute haemorrha gicnecrotizing pancreatitis induced by Na-Tcin rats was still a primary inflammatoryresponse.