视神经损伤后修复与再生的研究进展

视神经损伤后的治疗和功能恢复是医学领域的历史性难题。由于作为中枢神经系统一部分的视神经损伤后缺乏神经修复和再生所需的微环境,为此,有效的神经保护、防止神经元死亡和促进神经修复至关重要。大量研究证明:视功能的恢复与视网膜神经节细胞(retinal ganglion cells,RGCs)的损伤程度、轴浆转运物质合成功能状态、自身修复和再生能力均密切相关。近10a来,随着对神经损伤机制的深入了解,各类神经保护的研究也有了很大进展,在治疗视神经损伤方面展现出诱人的前景。我们通过阅读近年国内外相关文献,针对视神经损伤后RGCs再生及视神经保护相关实验研究和临床治疗方法作一综述。

Recent advances on the empirical study of the optic nerves' reparation and regeneration following injury

The therapy and functional recovery of optic nerve injury is a historical tough problem. Because after the optic nerves, as a part of central nervous system, were injured, the optic nerves were short of the microenvironment which nerves need to repair and regeneration. For that, it is very important that the effective nerves' protection, the prevention of neurons' death and to promote nerves' renovation. A great quantity of investigation has demonstrated that the visual function's recovery is closely related to the injury degree of retinal ganglial cells(RGCs), the axoplasm conveying materiae synthesis functional status, the self reparation capability and the self regeneration capability. In the recent decade, with the comprehending to the injury mechanism of nerves, a kind of researches in nerve preserved showed fairly advancements, which have revealed an excellent perspective in the part of healing the optic nerve injury. We read the recent pertinent literatures in the country of exterior and interior and composed a review concerning with the empirical study and the clinical therapy correlated to the RGCs' regeneration, the optical nerves' protection after the optic nerves injured.