灵芝对高血压病胰岛素抵抗干预作用的研究

目的 :探讨灵芝对 EH病人 IR的干预作用及可能机制。方法 :测定 42例 EH病人服用灵芝前后 G、INS等生化指标的改变。同时观测大动脉、小动脉、毛细血管压、毛细血管密度、输入枝口径及全血粘度、血浆粘度等指标。结果 :与空白对照组比较 ,EH病人降压辅以中药灵芝治疗后 ,大动脉、小动脉、毛细血管压明显降低 :毛细血管密度、口径增大 ,全血、血浆粘度降低 (P〈0 .0 5 -0 .0 1) ;G-AUC、I-AUC缩小其比例增大 ,空腹 INS降低 ,ISN升高 (P〈0 .0 5 -0 .0 1)。结论 :灵芝具有调节 EH病人微循环增加毛细血管密度、降低血浆粘度 ,协同降压 ,改善 IR的作用

EFFECTS OF LINZHI ON lNSULIN RESISTANCE IN PATIENTS WITH ESSENTIAL HYPERETENSION

Object To study effects of Linzhi on insulin resistance(IR) in patients with essential hypertension(EH).Methods Forty tow patients with EH　were included in the study.Serum glucose(G)、insulin(Ins)、insulin sensitive index(ISI)were determined.and Arterial(BP)、Arteriolar(ZBP)、Capillary blood pressure(CBP)、Capillary loop density(DD)、diameter(DM)、blood viscosity(b)、plasma viscosity(p)were also measured.Treated by Linzhi in patients of EH. Results compared with control group.After treatment of Linzhi combined with the routine hypertensor 3 months,BP、ZBP、CBP、b、p、fasting-Ins、G-AUC、I-AUC were significantly lower(p〈0.05-0.01),G/Ins、G-AUC/I-AUC、ISI、DD、DM were significantly higher(p〈0.05-001),Conclusion There were impaired glucose tolerance,hyperinslinemia,insulin resistance in EH and Linzhi displayed synergistic action with the hypertensor,increases of Capillary loop density,decreases of plasma viscosity improvement of　microcirculatory perfusion are responsible for alleviation of IR of EH.