11例粘质沙雷菌医院感染的治疗

目的研究粘质沙雷菌引起医院感染的原因、耐药特点及治疗方案. 方法收集我科 2002年6～9月11例患者42株粘质沙雷菌培养结果,分析其药敏情况,并结合临床治疗过程总结治疗方案. 结果42株细菌药敏结果高度一致,其MIC值亦非常一致,因此本次感染为医源性感染;经过彻底消毒、加强感染管理得以控制. 结论粘质沙雷菌易引起院内流行性感染;粘质沙雷菌导致的败血症患者使用氨基糖苷类药物与亚胺培南/西司他丁、头孢三代、喹喏酮类联用效果显著;粘质沙雷菌的耐药性各单位差异较大,须根据实际情况选用抗生素.

Treatment of Nosocomial-infection due to Serratia marcescens:An 11 Case Analysis

OBJECTIVE To explore the cause, the characteristics of drug resistance and the treatment of nosocomial infection due to Serratia marcescens (SM). METHODS Forty two SM strains from 11 cases in our ward from Jun 2002 to Sep 2002, were collected cultured and summed up the therapy according to the clinic treatment. RESULTS The drug resistance of 42 strains was extraordinarily coincident. The infections were controlled after complete disinfection and enhancing the infection management. CONCLUSIONS SM can cause the nosocomial epidemic infection. The application of aminoglycosides combined with imipenem/cilastatin(Tinem), or third generation cephalosporins or quinolones will be effective. There is markly difference of the SM drug resistance among hospitals, we must choose the antibiotic according the practical condition.