| MGMT和Ki-67抗原在肝细胞癌组织中的表达及意义 |
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| 引用本文： | 宋德霸,赵龙栓,王万鹏,朱志杰,黄修明,谷渊.MGMT和Ki-67抗原在肝细胞癌组织中的表达及意义[J].肿瘤基础与临床,2009,22(6):461-463. |
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| 作者姓名： | 宋德霸 赵龙栓 王万鹏 朱志杰 黄修明 谷渊 |
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| 作者单位： | 郑州大学第一附属医院肝胆外科,河南,郑州,450052 |
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| 摘 要： | 目的 探讨O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)和细胞增殖核抗原Ki-67在原发性肝细胞肝癌(HCC)组织中的表达及意义.方法 应用免疫组化S-P法检测68例HCC组织及癌旁组织中MGMT及Ki-67抗原的表达.结果 MGMT、Ki-67抗原在HCc组织中的表达率分别为44.12%(30/68)和57.35%(39/68),MGMT的表达与Hcc组织病理分级有关(P<0.05),与其它临床因素无关(P>0.05);Ki-67抗原的表达与HCC的肿瘤大小、包膜是否完整、脉管有无癌栓、病理分级有关(P<0.05),与血清AFP的浓度无关(P>0.05);并且随Ki-67抗原表达强度的增加,MGMT的表达强度明显下降,Ki-67抗原与MGMT表达呈负相关(γ=-0.301,P<0.05).结论 MGMT在HCC的发生发展中可能起抑制作用,MGMT的缺失是HCC发生的重要分子事件之一,检测Ki-67抗原有助于判断HCC恶性程度及复发转移的风险,联合检测MGMT和Ki-67抗原有助于预测HCC患者预后.
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| 关 键 词： | O6-甲基鸟嘌呤-DNA甲基转移酶 Ki-67抗原 肝细胞癌 免疫组化 |
The Expressions and Clinical Significances of MGMT and Ki-67 Antigen in Human Hepatocellular Carcinoma |
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| Song Deba,Zhao Longshuan,Wang Wanpeng,Zhu Zhijie,Huang Xiuming,Gu Yuan.The Expressions and Clinical Significances of MGMT and Ki-67 Antigen in Human Hepatocellular Carcinoma[J].journal of basic and clinical oncology,2009,22(6):461-463. |
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| Authors: | Song Deba Zhao Longshuan Wang Wanpeng Zhu Zhijie Huang Xiuming Gu Yuan |
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| Institution: | Song Deba,Zhao Longshuan,Wang Wanpeng,Zhu Zhijie,Huang Xiuming,Gu Yuan(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | Objective To investigate the expressions and clinical significances of MGMT and Ki-67 antigen in human HCC.Methods Sixty eight specimens of human HCC were selected.The expressions of MGMT and Ki-67 antigen were observed with immunohistochemical technique,and the relation between MGMT and Ki-67 antigen was evaluated.Results The expressions of MGMT and Ki-67 antigen were 44.12%(30/68) and 57.35%(39/68) respectively in HCC.The expressions of MGMT in HCC were related to histopathological grade,but there was no ... |
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| Keywords: | O6-methyl guanine-DNA methyltransferase Ki-67 antigen hepatocellular carcinoma immunohistochemistry |
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