Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children |
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| Authors: | Tetsuo Nakayama Takuji Kumagai Ken J. Ishii Toshiaki Ihara |
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| Affiliation: | 1. Kitasato Institute for Life Sciences, Laboratory of Viral Infection, Tokyo, Japan;2. Kumagai Pediatric Clinic, Sapporo, Japan;3. National Institute of Biomedical Innovation, Laboratory of Adjuvant Innovation, Osaka, Japan;4. Osaka University, Immunology Frontier Research Center, Laboratory of Vaccine Science, Osaka, Japan;5. National Mie Hospital, Department of Pediatrics, Tsu, Mie Prefecture, Japan |
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| Abstract: | IgG subclass antibody responses are not fully understood. Alum-adjuvanted H5N1whole virion inactivated vaccine (WIV), a genetically reassortant vaccine seed strain originating from H5N1/A/Vietnam/1194/2004 and PR-8, induced significantly stronger antibody responses in neutralizing antibodies in children. In this report, IgG subclass antibody responses were investigated, and most serum samples were positive for IgG1 antibody before immunization. A significant response (more than 4-fold increase) of IgG1 antibody was observed in 67/193 (34.7%) and that of gG4 antibodies in 42/193(21.8%). Children <4 years of age showed a significant increase in IgG subclass antibodies but those ≥4 years showed lower responses. Alum- adjuvanted H5N1WIV induced an efficient immune response in young children especially <4 years. |
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| Keywords: | H5N1 Whole virion inactivated influenza vaccine IgG subclass antibody Th1 and Th2 balance |
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