泮托拉唑联合多潘立酮、铝碳酸镁片治疗胆汁反流性胃炎

观察联合应用多潘立酮、泮托拉唑和铝碳酸镁治疗胆汁反流性胃炎（BRG）的疗效，探讨药物作用机制。方法：80例BRG患者随机分为观察组与对照组各40例。观察组给予泮托拉唑胶囊、铝碳酸镁片、多潘立酮片治疗，对照组给予铝碳酸镁片、多潘立酮片治疗。4周后观察两组的治疗效果。结果：治疗后，观察组有效率为92．5％，高于对照组的62．5％（P〈O．05）；两组治疗后胃黏膜充血、水肿、糜烂情况均有明显改善（P〈0．05），且观察组较对照组改善更显著（P〈0．05）；两组治疗后胃液胆酸含量、胃酸分泌量均较前明显降低（P〈0．05），而观察组胃酸分泌量明显更低于对照组（P〈0．05）。结论：多潘立酮、泮托拉唑和铝碳酸镁片联合用药可有效减轻患者的临床症状，减少胃酸分泌，明显改善胃镜下黏膜炎症，临床效果明显优于多潘立酮和铝碳酸镁两药联用。

Efficacy of Domperidone Combined with Pantoprazole and Hydrotalcite Tablets in the Treatment of Bile Reflux Gastritis

To observe the curative effects of the combined application of domperidone, pantoprazole and hydrotalcite tablets in the treatment of bile reflux gastritis （BRG） and explore the underlying mechanism. Methods： Totally 80 patients with BRG were randomly divided into the treatment group and the control group with 40 cases in each. The treatment group was received panto- prazole, hydrotalcite tablets and domperidone, and the control group was treated by hydrotalcite tablets and domperidone. The efficacy was observed in both groups after 4 weeks. Results ： The effective rate of symptom relief in the treatment group and the control group was respectively 92.5% and 62.5% （P 〈 0.05 ）. After the 4 week treatment, the gastritis healing rate in the treatment group was higher than that in the control group （P 〈 0.05）. The improvement of gastric mucosal hyperemia, edema and erosion in the treatment group was better than that in the control group with significant difference （ P 〈 0.05 ）. Cholic acid in gastric juice and gastric acid secretion were significantly reduced in both groups after the treatment, while the reduction of gastric acid secretion in the treatment group was more notable than that in the control （P 〈 0.05）. Conclusion ： Pantoprazole can be used to control BRG, and the combination of the three drugs shows better efficacy in the treatment of BRG.