二甲双胍与瑞格列奈治疗老年糖尿病患者疗效比较

探讨二甲双胍治疗老年糖尿病患者的疗效及安全性。方法：72例老年糖尿病患者随机分为观察组与对照组各36例。观察组采用二甲双胍片治疗，对照组给予瑞格列奈片，疗程均为8周。比较两组的疗效及安全性。结果：两组治疗后空腹、三餐后2h及晚10点时的血糖值均较前显著下降（P〈0．05）；观察组治疗后空腹血糖水平明显低于对照组（P〈0．05），其他时间点血糖值与对照组比较差异无统计学意义（P〉0．05）。观察组治疗后HbAle水平明显低于治疗前（P〈0．05），对照组治疗前后HbAlc水平差异无统计学意义（P〉0．05）。观察组药品不良反应发生率低于对照组，差异有统计学意义（P〈0．05）。结论：二甲双胍在治疗老年患者糖尿病治疗中效果显著，安全性高，值得进一步推广应用。

Effect Comparison of Metformin and Repaglinide in the Treatment of Elderly Diabetic Patients

To investigate the efficacy and safety of metfonnin in the treatment of elderly patients with diabetes. Meth-ods： Totally 72 cases of elderly patients with diabetes in our hospital from January 2012 to December 2012 were randomly divided into the observation group and the control group. The observation group was received metformin, and the control group was given repaglinide. The efficacy and safety of the two groups were compared. Results： After the treatment, blood sugar of fasting, 2h after meals and 10：00 p.m. in the observation group and the control group was significantly decreased （P 〈 0.05）, and blood sugar of fasting in the observation group was significantly lower than that in the control （ P 〈 0.05 ）, while that of the other time points was without significant difference （ P 〉 0.05 ）. The HbA1 c levels before and after the treatment in the observation group was with statistically significant difference （ P 〈 0.05 ）, and those in the control group was without significant difference （ P 〉 0.05 ）. The incidence of adverse reactions in the observation group was lower than that in the control group（P 〈 0.05）. Conclusion： Effect of metformin in the treatment of elderly patients with diabetes is remarkable and safe, which is worthy of further promotion and application.