血管内皮生长因子-C在分化型甲状腺癌的表达及意义

目的:探讨血管内皮生长因子C(vascular endothelial growth factor-C,VEGF-C)蛋白在分化型甲状腺癌组织中的表达及与临床病理特征的关系及意义?方法:应用免疫组化SP法检测50例甲状腺乳头状癌(papillary thyroid cancer,PTC)?50例甲状腺滤泡状癌(follicular thyroid cancer,FTC)和20例正常甲状腺(NT)组织VEGF-C蛋白的表达?结果:VEGF-C在PTC?FTC?NT组织的表达不一,阳性率分别为48.0%?24.0%?10.0%(P < 0.05);PTC组织的VEGF-C阳性率在淋巴结转移组为85.7%,高于无转移组的40.0%及骨或肺转移组的50.0%(P < 0.05);FTC组织的VEGF-C阳性率在淋巴结转移组为57.1%,高于无转移组的17.1%及骨或肺转移组的25.0%(P < 0.05);PTC与FTC组织的VEGF-C表达差异主要存在于无转移及骨或肺转移组(P < 0.05)?结论:VEGF-C与分化型甲状腺癌的淋巴结转移密切相关,在分化型甲状腺癌的淋巴道转移中起着重要的作用?PTC组织VEGF-C表达明显高于FTC组织,可以解释两者不同的淋巴结侵犯倾向?分化型甲状腺癌组织VEGF-C高表达可能可以预测其淋巴结转移?

Expression and significance of VEGF-C in differentiated thyroid cancer

Objective:To investigate protein expression and significance of vascular endothelial growth factor-C (VEGF-C) in differentiated thyroid cancer(DTC) and its relationship with clinicopathologic features. Methods:The expression of VEGF-C in 50 papillary thyroid cancer(PTC),50 follicular thyroid cancer(FTC) and 20 normal thyroid (NT) tissue specimens were detected by SP immunohistochemistry. Results:The positive rates of VEGF-C in PTC,FTC and NT tissues were significantly different (48.0% vs 24.0% vs 10.0%,P < 0.05). The positive rates of VEGF-C were higher in PTC with lymph node metastases than PTC without metastases and PTC with bone or lung metastases(85.7% vs 40.0% or 50.0%,P < 0.05). The positive rates of VEGF-C were higher in FTC with lymph node metastases than FTC without metastases and FTC with bone or lung metastases (57.1% vs 17.1% or 25.0%,P < 0.05). The difference between PTC and FTC was mainly found between groups without metastases and with bone or lung metastases(P < 0.05). Conclusion:VEGF-C is closely related to lymph node metastasis of DTC,and may play an important role in lymph node metastasis of DTC. The expression of VEGF-C is higher in PTC than FTC,and can explain the different propensities to lymph node metastasis of PTC and FTC. High expression of VEGF-C in tumor tissue may be a predictor of lymph node metastasis of DTC.