| 胃癌中水通道蛋白3的表达与淋巴结转移的关系 |
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| 引用本文： | 徐 勇,张文杰,杨 力,徐泽宽,徐 皓.胃癌中水通道蛋白3的表达与淋巴结转移的关系[J].南京医科大学学报,2012(4):454-457. |
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| 作者姓名： | 徐 勇 张文杰 杨 力 徐泽宽 徐 皓 |
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| 作者单位： | 南京医科大学第一附属医院普外科,江苏 南京 210029;南京医科大学第一附属医院普外科,江苏 南京 210029;南京医科大学第一附属医院普外科,江苏 南京 210029;南京医科大学第一附属医院普外科,江苏 南京 210029;南京医科大学第一附属医院普外科,江苏 南京 210029 |
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| 基金项目： | 国家自然科学基金资助(30901421);江苏省卫生厅开放课题(XK03200903) |
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| 摘 要： | 目的:探讨水通道蛋白3(AQP3)在胃腺癌不同分期中的差异表达与淋巴结转移的关系?方法:采用定量PCR?Western blot法对80例不同分期的胃腺癌组织及作为对照的癌旁非肿瘤组织中AQP3 mRNA和蛋白的表达分别进行检测,并与各临床病理分期中淋巴结转移情况进行分析?结果:AQP3在胃腺癌不同分期中的差异表达影响胃癌的淋巴结转移,有淋巴结转移的T1?T2?T3?T4期(UICC,2010)肿瘤组织中AQP3的表达明显高于无淋巴结转移者?结论:胃腺癌肿瘤组织中高表达的AQP3可能对患者淋巴结转移的发生有促进作用,因此AQP3有望成为预测胃腺癌转移和评估预后的重要指标,并可能是胃癌治疗靶点之一?
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| 关 键 词： | 水通道蛋白3 胃腺癌 淋巴结转移 |
| 收稿时间： | 2011/10/29 0:00:00 |
Expression of aquaporin-3 in gastric adenocarcinoma and the relationship with lymph node metastasis |
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| XU Yong,ZHANG Wen-jie,YANG Li,XU Ze-kuan and XU Hao.Expression of aquaporin-3 in gastric adenocarcinoma and the relationship with lymph node metastasis[J].Acta Universitatis Medicinalis Nanjing,2012(4):454-457. |
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| Authors: | XU Yong ZHANG Wen-jie YANG Li XU Ze-kuan and XU Hao |
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| Institution: | Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China;Department of General Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China |
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| Abstract: | Objective:To investigate the expression difference of aquaporin-3(AQP3) in each stage of gastric adenocarcinoma(GAC),and the relationship with lymph node metastasis. Methods:Collecting 80 cases of gastric adenocarcinoma tissue and corresponding nontumor tissue,the AQP3 expression of mRNA and protein in each sample were detected by quantitative real time polymerase chain reaction(qPCR) and Western blot. Then,the relationship between AQP3 expression and clinicopathologic characteristics of the patients was analyzed. Results:The different expressions of AQP3 in each stage of GAC (T1,T2,T3,T4),according to UICC(2010),had effects on lymph node metastasis;The expression of AQP3 in tumor tissue with lymph node metastasis was higher than that without lymph node metastasis. Conclusion:The overexpression of AQP3 in GAC might stimulate the occurrence of lymph node metastasis. The overexpression of AQP3 can be taken as a biomarker of GAC prognosis and metastasis. AQP3 might be a therapy target of gastric adenocarcinoma. |
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| Keywords: | aquaporin-3(AQP3) gastric adenocarcinoma(GAC) lymph node metastasis |
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